The Pick of Destiny can accept a few modifications, listed below: This is offset by its long range, capable of hitting zombies well out of their own reach, meaning for fighting large enemies like Thugs or a group of Walkers, the Pick of Destiny does well, sometimes more so than a sledgehammer.
While its damage is high for a two handed weapon, especially a two handed blunt weapon, it is still lower than a regular one handed or even lighter two handed weapon like the metal kanabo or big baseball bat. It is also a slow attacking weapon, so for fighting Infected or fast zombies like the Butcher, the Pick of Destiny is a poor choice. Since it's a two handed weapon, it's got high force but also requires a lot of stamina to swing. Compared to regular pickaxes, since the Pick of Destiny is a legendary version, it is superior in every regard, even to an orange 'legendary' regular pickaxe.